TAMSULOSIN HYDROCHLORIDE

TAMSULOSIN HYDROCHLORIDE
PRODUCT IDENTIFICATION
CAS NO.	94666-07-6, 106138-88-9 (parent) 106463-17-6 (hydrochloride)
EINECS NO.
FORMULA	C₂₀H₂₈N₂O₅S · HCl
MOL WT.	444.97
TOXICITY	Oral Rat LD50: 650mg/kg
H.S. CODE	2935.00.6000
SYNONYMS	Tamsulosin hydrochloride; Omic; Omix; Omnic;
Alna; Amsulosin hydrochloride; Tamsulosin HCl; (-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)ethyl)amino) propyl)-2-methoxybenzene sulfonamide monohydrochloride; R-(-)-5-(2-((2-(2-Ethoxyphenoxy) ethyl) amino) propyl)-2- methoxy benzenesulfonamide hydrochloride; Flomax; Urolosin; Other RN: 112101-78-7, 128332-25-2
SMILES	c1(c(ccc(c1)C[C@H](NCCOc1c(cccc1)OCC)C)OC)S(N)(=O)=O.Cl
CLASSIFICATION	Adrenergic agent, Adrenergic antagonist, Adrenergic alpha-antagonist, Antineoplastic,
EXTRA NOTES	Benign prostatic hyperplasia therapy agent. An alpha 1 adrenoreceptor blocker; approved for treatment of benign prostatic hyperplasia; floppy iris syndrome during cataract surgery has been noted.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT	230 - 232 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
SOLVENT SOLUBILITY
pH
VAPOR DENSITY
REFRACTIVE INDEX
NFPA RATINGS	Health hazard: 2, Fire: 0, Reactivity Hazard: 0
AUTOIGNITION
FLASH POINT
STABILITY	Stable under normal conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Tamsulosin hydrochloride http://www.sigmaaldrich.com/ Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome. http://www.amcp.org/ Multicenter Drug Use Evaluation of Tamsulosin and Availability of Guidance Criteria for Nonformulary Use in the Veterans Affairs Health System http://www.drugbank.ca/ Mechanism of action: Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men.
SALES SPECIFICATION
APPEARANCE	white to off-white crystalline powder
ASSAY	99.0% min
MELTING POINT	230 - 232 C
LOSS ON DRYING	0.5% max
OPTICAL ROTATION	-3.5° ~ -4.5°
IMPURITY	Individual Impurity: 0.3% max Total Impurity: 1.0% max
WATER	0.5% max
HEAVY METALS	10ppm max
RESIDUE ON IGNITION	0.25% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
GHS
SIGNAL WORD	Warning
PICTOGRAMS
HAZARD STATEMENTS	H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
PRECAUTIONARY STATEMENTS	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
EC DIRECTIVES
HAZARD CODES	Xn Harmful
RISK PHRASES	22 Harmful if swallowed 36/37/38 Irritating to eyes, respiratory system and skin
SAFETY PHRASES	26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
PRICE INFORMATION